Inhibitors of mammalian protein synthesis.

EFFECTS OF SERUM AND PROTEIN SYNTHESIS INHIBITORS ON POLYMORPHONUCLEAR NEUTROPHIL APOPTOSIS

In this study the programmed cell death (apoptosis) of human neutrophilic granulocytes was investigated in the presence and absence of fetal calf serum (FCS), cycloheximide and actinomycin-D. The results show that when FCS is omitted from cultures, apart from a decrease in viability, the percentage of apoptotic cells and DNA fragmentation increases. Apoptosis is accelerated in serum withdra...

A STUDY ON THE HEMOPOI ETIC ACTIVITY OF HUMAN PLACENTA IN VITRO, IN THE PRESENCE AND ABSENCE OF STIMULATORS AND INHIBITORS OF TRANSCRIPTION AND TRANSLATION

The hemopoietic activity of the human placenta was studied in vitrc under various conditions in order to assess the optimal conditions of protein synthesis and colony stimulating factor (CSF) production by this tissue. The hemopoietic activity of placental tissue was assayed by the semi -solid agar medium technique. In order to obtain maximum hemopoietic activity, various stimulators were ...

Antagonism between DNA synthesis inhibitors and protein synthesis inhibitors in mammalian cell cultures.

Development of 1,2,4-triazole-5-thione derivatives as potential inhibitors of enoyl acyl carrier protein reductase (InhA) in tuberculosis.

Tuberculosis (TB) ranks second, next to AIDS making it most formidable disease if the present age. One of the crucial enzymes involved in cell wall synthesis of Mycobacterium tuberculosis, InhA (enoyl acyl carrier protein reductase) has been authenticated as an effective target for anti-mycobacterial drug development. In the current work, we have developed novel derivatives of 1,2,4-triazole-5-...

Development of 1,2,4-triazole-5-thione derivatives as potential inhibitors of enoyl acyl carrier protein reductase (InhA) in tuberculosis.

Tuberculosis (TB) ranks second, next to AIDS making it most formidable disease if the present age. One of the crucial enzymes involved in cell wall synthesis of Mycobacterium tuberculosis, InhA (enoyl acyl carrier protein reductase) has been authenticated as an effective target for anti-mycobacterial drug development. In the current work, we have developed novel derivatives of 1,2,4-triazole-5-...

The effect of high intensity interval training on complex mammalian target of Rapamycin 1 (mTORC1) pathway in Flexor hallucis longus muscle (FHL) of streptozotocin-induced diabetic rats

Background and Objective: The most well-known mechanism for regulating complex mammalian target of rapamycin 1 (mTORC1) pathway activity is the insulin/IGF-1-dependent pathway in skeletal muscles. The role of high intensity interval training (HIIT) exercise has not yet been studied on this important pathway in protein synthesis among people with type 2 diabetes. The purpose of the present study...